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Superflu?

 
  

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grant
15:04 / 17.04.03
Might be worth pointing out that erythromycin is over the counter in China.

Although antibiotics really don't have anything to do with a viral disease. Unless, say, SARS had some bacteria component, which I don't think is likely.

Soma Irot: check the FAQs link at the top of the page for linking advice.
 
 
mombius hibachi
12:35 / 18.04.03
Hello everybody. This is my first post, so be gentle.

I read on the following page that in Hong Kong 80-90% of cases were "responding well" to a mix of anti-viral drugs and steriods.

http://www.washingtonpost.com/wp-dyn/articles/A29697-2003Apr15.html

Also, apparently some folk remedy doing the rounds in China at the moment is to have a slow-boiler filled with vinegar percolating away in the background. This was told to me by a friend who is teaching over there. The students insist on having all the windows shut, all day, having been educated in SARS-prevention methods which may or may-not work by their parents.

Facemasks are really common, too, especially in Shanghai.

The city I'm moving to next week. Impeccable timing on my part, I must say.
 
 
grant
17:24 / 18.04.03
If it's any comfort, facemasks are pretty common in other industrial centers in Asia (Taiwan especially) due to air pollution.

And howdy!
 
 
Thjatsi
23:59 / 19.04.03
Sorry about the very late response, I’ve had a lot of things to work on lately.

...antibiotics are like giving your immune system speed while in combat.

Eh? Antibiotics kill bacteria, but don’t necessarily act on the immune system. Giving someone cytokines or some sort of interferon could perhaps be compared to speed, but I don’t see how penicillin could be.

The trouble is that they knacker other parts of your system...

I think you could make the case that they negatively impact the bacteria that live in your gastrointestinal tract. Aside from that minor problem, I haven’t ever come across this idea, and would like to see some evidence on this.

...they also screw about with the bodies balance.

Which homeostatic mechanism do they alter?

Is it again unreasonable to speculate in this direction in relation to the increased prevalence of autoimmune diseases in our society?

There’s nothing wrong with speculating, I just want some evidence to back it up.

A comforting perspective, but alas erroneous.

Then why is age the biggest risk factor for cancer?

As far as I understand it there is another epidemic that will surely kill as effectively as any flu but far more slowly and that is obesity.

Thankfully, it will only kill people unwilling to regulate their metabolic activity either by exercising more or eating less. However, I should point out that I am trying to get rid of my American flab as I write this.

1 in 6 kids has asthma in the UK which is.....interesting.

It is interesting, but the possibility that this is caused by the overuse of antibacterial agents is still very controversial.

In this centuary we are almost certain to see the return of TB and a whole host of antibiotic resistant bacteria

This is dependent upon whether these bacteria can adapt to resist all antibiotics. In addition, new antibiotics are being made on a regular basis. It may turn out to be a serious problem, or we might be worrying over nothing.

So are you then saying that there aren't areas that have
1] a greater density of microbial action
2] that it isn't an important issue immune system-wise running into utterly novel microbes.......like say the native americans and smallpox?


For your first question no I'm not saying that at all. Last time I heard this was the breakdown of the estimated 10^30 bacteria on the planet:

Air: 10^19
Human Associated: 10^22
Other Animals: 10^24
Soil: 10^29
Ocean: 10^29
Subsurface: 6.5 * 10^29

So, if we're just worried about microbe density we should be avoiding the ocean and the inside of the earth as much as possible.

For your second question, I recognize that animals act as reservoirs for diseases. However, it is my opinion that we’ve already run into the vast majority of things that we could potentially encounter.

That said you don't really have to silence everyone at an individual level you simply don't allow it into the mass media, in this country it's called a D notice.

I'm not too familiar with the British media. However, isn't it true that the D notice is voluntary, and that not all news providers are involved?

Seems like yeah, bushmeat has been documented as a disease vector.

I’m not going to argue with the World Health Organization.
 
 
grant
15:32 / 21.04.03
There's more SARS info here, on this Conversation thread about going to Thailand.

Thjatsi: However, it is my opinion that we’ve already run into the vast majority of things that we could potentially encounter.

Probably true, but microbes keep on mutating. It seems likely (my opinion) that SARS hasn't been around for a long while, that it's just a new draft of the same old common cold story, slightly rewritten for extra lethality.
 
 
Thjatsi
02:37 / 22.04.03
However, the common cold has a bit of a selection advantage, since it generally doesn't doesn't kill its host.
 
 
gravitybitch
04:20 / 22.04.03
Doesn't much matter if the host dies, as long as the disease gets passed on before the host dies... although there does seem to be some selection towards non-lethality taking place.
 
 
grant
13:21 / 22.04.03
I might have to amend myself:
The latest Nature says they've gotten the virus' genome, and it seems likely it came from animals. One researcher is quoted as saying it "might have been around for millennia."

Personally, I prefer the idea that it's a mutant common cold, but I'm not gonna argue with a microbiologist on that.
 
 
Thjatsi
05:07 / 23.04.03
Doesn't much matter if the host dies, as long as the disease gets passed on before the host dies...

It matters for reinfection. You can get the flu more times than you can get AIDS. Evolutionary fitness is partially dependent upon reinfection, and a virus that can do this will have a selective advantage over one that cannot.
 
 
grant
13:51 / 05.05.03
New Scientist reports: SARS kills by turning immune system against itself.

Microbial judo - gotta hate that. I believe that's also what MS does - turns the immune system against (specifically) nerve cells. SARS hits the lungs:

Mark Salter, WHO's coordinator for the clinical management of SARS, told New Scientist that this excessive response seems to be destroying the alveoli, the tiny sacs at the end of the lung tubing where the oxygen is absorbed. It is like stripping all the leaves from a tree, he says, making breathing extremely difficult.

On the plus side, this suggests a new angle of treatment:

Corticosteroids suppress the immune system and are normally used against asthma, rheumatoid arthritis and in transplant patients to reduce the risk of rejection.

Their use does raise the risk of further infection, but Hong Kong hospitals are claiming success with combinations of the antiviral ribavirin and pulsed steroids, says Salter: "And once steroids are stopped, they see a flare up of the condition suggesting there is a significant immune component to the disease."



They've also found the bug can stay active for up to 24 hours outside a human body. Like stuck to the pole on a subway car. Or on the arms of an airplane seat.
 
 
Baz Auckland
16:08 / 23.05.03
SARS linked to small mammals

Researchers from the University of Hong Kong examined 25 animals representing eight species in a live animal market in southern China and found the virus in all six masked palm civets they sampled, as well as in a badger and a raccoon dog.

"All these animals could have been infected by feed which was given to them at the market," Stohr said. "Very often these markets have one major supplier of feed."

He added that a recent study from Guangdong province in southern China — where the SARS outbreak first emerged in November — indicated that more than 30 percent of the early SARS cases there were food handlers.

"This is corroborative evidence that there make be a link between the wildlife and the emergence of SARS." Civet cats are nocturnal animals related to the mongoose, with long tails and catlike bodies. They resemble small raccoons or weasels.
 
 
grant
17:42 / 10.05.04
SARS is linked to sweat.

So it might spread a little easier than we thought:
Researchers already know that SARS can disperse through faeces and droplets from coughs. But these results suggest that a simple touch could also spread the disease, says team leader Shibo Jiang at the New York Blood Center. To prevent this, he suggests that additional protective measures should be taken, such as requiring patients to wear gloves and gowns.



The WHO says current protocols are enough to keep the disease in check (wearing a mask and frequent handwashing being the main ones).

Still, it's a little disconcerting, as discoveries go.
 
  

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