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Microbiological War Zone: Phage Therapy Kills Bugs Dead

 
 
grant
17:59 / 22.04.02
From Nature:

excerpt:
Long-abandoned by Western medicine, viruses that naturally kill microbes are being imported as a potential substitute for antibiotics.

The emergence of multi-drug-resistant bacteria is intensifying the search for antibiotic replacements. Bemoaning the problem, clinician Glenn Morris of the University of Maryland in College Park got an idea from a colleague from the former Soviet republic of Georgia. Morris explains: "He said, 'why don't you use 'phage therapy?'; I said, 'what's 'phage therapy?'."

'Phages - more properly, bacteriophages - are viruses that are harmless to humans but kill bacteria. They were widely researched as a means to tackle disease until the 1940s. When potent antibiotics appeared on the scene, the West discarded them.
 
 
grant
18:01 / 22.04.02
It's also worth mentioning that phage therapy is widely known and used in the former Soviet Union, but like other examples of weird Soviet science, isn't widely respected in the West.
 
 
The Sinister Haiku Bureau
00:05 / 23.04.02
Cool! I've been shitting myself intermittently over the prospect of a plague of antibiotic-imune bacteria for some time now. Now all we need to do is abolish nuclear weapons, get rid of W, find a cure for man's homicidal urges, and figure out a way to prevent the earth from getting hit by asteroids and i might actually be able to sleep at night!
Significantly off topic, but are you up for starting a general purpose weird-soviet-science-which-is-sneered-at-in-the-west thread? Or any links on this topic?
 
 
Thjatsi
02:11 / 23.04.02
You have to understand that Soviet Biology was a pretty sad state of affairs historically, and has only begun to get back on its feet in the last decade or so. My old genetics textbook explains the history of this problem rather nicely:

Trofim Denisovich Lysenko was a biologist in the former Soviet Union working on the effects of temperature on the development of plants. At the same time, the preeminent geneticist was Nikolai Vavilov. Valivov was interested in growing and mating many varieties and selecting the best to be the breeding stock of the next generation. This is the standard way of improving a plant crop or lifestock breed. The method conforms to genetic principles and therefore is successful. However, it is a slow process that only gradually improves yields.

Lysenko suggested that crop yields could be improved quickly by the inheritance of acquired characteristics. Although doomed to fail because the true and correct mechanisms of inheritance were denied, politically, Lysenko's ideas were greeted with much enthusiasm. The enthusiasm was due not only to the fact that Lysenko promised immediate improvements of crop yields but also to the fact that Lysenkoism was politically favored.

Supported by Stalin, and then Krushchev, Lysenko gained inordinate power in his country. All visible genetic research in the former Soviet Union was forced to conform to Lysenko's Lamarckian views. People who disagreed with him were forced out of power. Vavilov was arrested in 1940 and died in prison in 1943. It was not until Nikita Krushchev lost power in 1964 that Lysenkoism fell out of favor.

For thirty years, Soviet geneticists were forced into fruitless endeavors, forced out of genetics altogether, or punished for their heterodox views. Superb scientists died in prison while crop improvement programs failed, all because Lysenkoism was favored by Soviet dictators.


Taken from pages 6 - 7 of Principles of Genetics 6th Edition, by Robert H. Tamarin. Some nonimportant text was ommited from this quote.

So, you'll have to excuse biologists for being a little skeptical of some of the bizzare things the Soviet Union came up with during that time.

Anyway, as far as the antibacterial viruses go, they aren't exactly a Soviet only endeavor. For example, James D. Watson, one of the scientists that discovered the structure of DNA, worked pretty extensively on these at one point in his life. On page 25 of his book, The Double Helix, he states:

At times, moreover, I was quite pleased with my current experiments on bacterial viruses. Within three months Ole and I had finished a set of experiments on the fate of a bacterial-virus particle when it multiplies inside a bacterium to form several hundred new virus particles. There were enough data for a respectible publication and, using ordinary standards, I knew I could stop work for the rest of the year without being judged unproductive.
 
 
Lionheart
17:20 / 27.04.02
You obviously missed a very important part of that article. That Lysenkoism fell out of favor in 1964. That was 27 more years before the collapse of the Soviet Union. So saying that Soviet Biology has gotten back on its feet in the last decade is wrong. I mean, the Soviet Union fell a decade ago, and because of that a lot of government funding to scientific programs was cut. In reality Soviet Biology got back on its feet right after 1964.
 
 
Thjatsi
02:40 / 28.04.02
I didn't miss a thing. The fact of the matter is that you can't suppress scientific thought at gunpoint for a few decades, and then say, "Oh we changed our minds, go back to thinking again". There are a few things that you're missing when you say:

In reality Soviet Biology got back on its feet right after 1964.

1) At that point in history the Soviet Union, the group of Biologists entering the discipline had been taught Lamarckism instead of the more accurate model of Darwinian evolution. In addition, Lysenko suppressed the entire field of genetics, which is one of the main legs of modern Biology. Marxism and the Philosophy of Science: A Critical History states that: The science of genetics was denounced as reactionary, bourgeois, idealist and formalist. The combination of these two problems meant that the new batch of scientists didn't possess the ground knowledge required to be successful in their discipline.

2) The biologists who managed to survive Lysenkoism did so because they were either stupid, or afraid to stick their neck out for what they knew was true. Neither one of these are qualities of a good scientist, and they are especially undesireable in older scientists, who tend to be the leaders of their discipline.

3) Lysenko encouraged non-scientific thinking during his time in power.
Marxism and the Philosophy of Science: A Critical History explains that:

Lysenko was very much a part of this campaign, stirring up a negative attitude to basic research and virulently demanding immediate practical results. He was capable of the crudest anti-intellectualism, remarking on one occasion: "It is better to know less, but to know just what is necessary for practice." He also was inclined to enunciations of the wildest voluntarism: "In order to obtain a certain result, You must want to obtain precisely that result; if you want to obtain a certain result, you will obtain it .... I need only such people as will obtain the results I need". Older scientists were, of course, horrified at such talk, so utterly alien to the habits of mind in which scientific method was grounded.

With all these things in mind, it's little wonder that the Soviets needed a generation to get back up to speed. And, if anyone has any evidence that this was not the case, then I would certainly like to see it.

If you are interested in more information on this topic, Carl Sagan discusses the aftermath of Lysenkoism in detail in his book, The Demon Haunted World.
 
  
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