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Influence of belief on health

 
 
DrJab
08:52 / 11.03.08
Branching off from a discussion about the placebo effect in trials of anti-depressant efficacy.

topic 28224

It is amazing how little research there is into how placebos work. In the case of depression it seems quite logical that if the subject *believes* they are taking a drug that has an effect, they are more likely to report a benefit simply as a result of the relatively subjective nature of the outcome variable (depression scale). A similar thing seems to apply to studies of drugs to relieve pain or conditions such as chronic fatigue or irritable bowel syndrome. Unless there are objective physical measures established which identify the presence or at least severity of conditions like these, it will be very difficult to tease out the placebo effect itself...

Now, what the hell is happening when a patient's cancer goes into remission whilst being "treated" with a placebo? I think the answer is pretty obvious when the outcome is based on clinical interpretation and the study isn't double-blinded (as the expectation of a specific effect will skew the clinician's judgement one way or the other). Fortunately, clinical trials without double-blinding are much less common in recent times. In the case of such double-blind experiments it is less clear. I find it very tempting to accept that belief in the efficacy of the dummy treatment has a positive effect on the progression of the disease. Unfortunately, I have not had much luck tracking down evidence to support this hypothesis (that thought can influence disease progression/prognosis) other than the placebo effect itself...

If anyone on this board could offer such evidence I would be greatful!
 
 
ONLY NICE THINGS
11:12 / 11.03.08
There's a Cochrane Group report on the effectiveness of intercessionary prayer on chronic illness, I believe - from about 1997? Might be a place to start...
 
 
Lurid Archive
13:20 / 11.03.08
I'm not quite understanding the distinction between the placebo effect and the (positive) effect that belief has on health. They seem like broadly the same thing, in the absence of a specific mechanism.

Certainly (as I seem to remember reading), the placebo effect seems to be very much about the patient's belief. It seems to be stronger if the "doctor" seems confident of the efficacy of the treatment, it is stronger for needles than for pills, and generally stronger if there is a negative side effect. As I recall, there are interesting cases where a drug is initially believed to be effective and does well, and is later demonstrated via double blind tests to have no detectable effect and subsequently does much worse (outside of clinical trials).
 
 
DrJab
14:14 / 11.03.08
I think the distinction is that a lot of the time, the placebo effect can be explained away as the result of reporting bias rather than any "real" observable effect. That's what I meant by it being explainable in psychological/psychiatric studies (where measurements of the efficacy of the treatment rely on patients' own reported experience) and in studies where the double-blind is flawed (and the outcome relies on judgements made by the scientists who will tend to have a fairly specific expectation of result, e.g. biopsy or x-ray results).

In those trials where double-blinding seems reasonable and there is still a placebo effect, it is scientifically plausible (in some cases) to discount any observed effect as being coincidental. That is, we don't entirely know what "causes" a disease and it is known that some disease go into remission despite the absence of any apparent change in conditions. For example, it doesn't seem magickal/mystical/parapsychological to me to say that sometimes the body overcomes disease without any assistance.

I'd love to be able to accept that belief plays a causal role in such situations but to my mind there is not yet sufficient evidence to overcome my unfortunately necessary scepticism. I accept it is possible but I want to see objective evidence.

Anyways, to directly address your comment Lurid, I think that the general consensus in the medical community is that the placebo effect is simply the result of patients getting better naturally. This is why doctors around the world aren't exclaiming "OMG! we don't need chemotherapy to treat cancer, we just have to make patients *believe* they will get better and the placebo effect will do the rest!"

I am aware of observations that the effect seems greater when medics wear white coats/use needles etc. but what is needed here is a study of a single population where patients are given different types of placebos (one cannot compare between studies due to population differences). Are you familar of any such studies?
 
 
DrJab
14:20 / 11.03.08
Have tracked down:

15: Related Articles, LinksRoberts L, Ahmed I, Hall S.

Intercessory prayer for the alleviation of ill health.
Cochrane Database Syst Rev. 2000;(2):CD000368. Review. Update in: Cochrane Database Syst Rev. 2007;(1):CD000368.
PMID: 10796350 [PubMed - indexed for MEDLINE]

but pubmed has just crapped itself... suddenly requires a log in - wtf???
 
 
DrJab
14:53 / 11.03.08
Goddamn I am dominating this discussion. Well, I am bored at work and this is *far* more interesting!

Thanks for the suggestion Haus... I found Roberts L. Ahmed I. Hall S. Intercessory prayer for the alleviation of ill health.[update in Cochrane Database Syst Rev. 2007 and this is exactly what I find so discouraging:

There was no evidence that prayer affected the numbers of people dying from leukaemia or heart disease (OR 1.11, CI 0.79-1.56, n=1424). Intercessory prayer did not clearly decrease the odds of people with heart problems experiencing a bad or intermediate outcome (OR 0.8, CI 0.64-1.00, n=1444) but this finding was moved towards the null by inclusion of a negative assumption for those who were dropped from the analysis in one study.

There is a point here about differential drop-outs (where patients remove themselves from the study because they believe they are not getting any benefit - we see this in trials for anti-psychotics) and this can bias results. I need to read the full review to have an appreciation of what is happening... I can't get it right now
 
 
grant
16:50 / 11.03.08
Yeah, I have trouble getting good articles because of access to full-text.

There are some tantalizing results on scholar.google.com, though.
 
 
DrJab
17:56 / 11.03.08
It's a great shame - I never fully appreciated until now how limiting it is not having open access (I have access to a lot of journals through my job but certainly not all)...

Never fear, the trend is towards open access for all UK-funded research.
 
 
DrJab
18:26 / 11.03.08
Thanks for that search link grant...

Nice bit of syncronicity there: "E Harkness" in the second article listed in your link is a friend of mine... bizarro!
 
 
grant
19:26 / 11.03.08
Oh! Well, at least you have someone to ask!
 
  
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