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Barbecued monkey: animal populations as viral reservoirs

 
 
grant
14:35 / 16.06.03
I just read this National Geographic article about HIV genetic research into the origins of the HIV.

Apparently, it's a synthesis of two germs from monkeys that a chimp caught by eating monkeys. And then humans got the bug by eating chimps.

Scientists now say that the simian immunodeficiency virus (SIV) in chimpanzees (Pan troglodytes), which is believed to have been transmitted to humans to become HIV-1 -- the virus that causes AIDS -- didn't start its life in chimps. Instead, it was a product of separate viruses jumping from different monkey species into chimps, where they recombined to form a hybrid virus, according to a new study.

Researchers believe the chimpanzee virus is a hybrid of the SIVs naturally infecting two different monkeys, the red-capped mangabey (Cercocebus torquatus) and the greater spot-nosed monkey (Cercopithecus nictitans). Chimps eat monkeys, which is likely how they acquired the monkey viruses.


It reminded me of some of the discussion we'd had about the civet cat as the source of SARS infection in humans.

I thought it might be nice to start a thread on guerilla germs - them what hide & mutate just under our radar until BLAM!

Seems to be happening more often nowadays. Why's that?
 
 
Mourne Kransky
17:06 / 16.06.03
It is a puzzlement. My guess would be that it's less to do with any changes in animal viral mutation than rapid spread in human populations because of greater likelihood of and more rapid travel. The species jump might previously have led to a smaller, more localised outbreak but for those factors.

And that the hysteria builds in our modern mass-communication media. The viruses replicate the patterns of genetic distribution in a post-bicycle world. But I may be wholly wrong.

There's also the example of the Monkeypox, to which Cherry Bomb alerted me. Passed on in Africa by the eponymous monkeys, and also by squirrels. Recent U.S. outbreak blamed on prairie dogs.



Also, weren't the civet cats being farmed for food use? A wild population might be less prone, perhaps.

In the U.S. case there was, I think, some thought that the little critters were being similarly "farmed" for resale as pets.
 
 
LVX23
05:17 / 03.07.03
There seems to be a common link between cannibalism in a species or between near specii and bacterial/viral problems. Monkey brains are one example, mad cow is another. Start feeding cows the sleuce of their slaughtered brethren and they start wiggin out with encephalitis. I wonder if there are any anthro studies of modern day cannibal cultures?
 
 
grant
13:07 / 03.07.03
It's called kuru in humans, and has been the subject of a bit of study, particularly as it relates to CJD (Creutzfeld-Jakob Disease), the human brain disease linked to Mad Cow Disease.

It even has its own page at the National Institutes of Health.
 
 
grant
13:11 / 03.07.03
It should be noted, however, that kuru and Mad Cow are both caused by prions, rather than by bacteria or viruses. It's not so much a reservoir situation as a "don't eat the proteins you're made from" situation.
 
 
Perfect Tommy
07:39 / 05.07.03
Lately I've come to believe that factory farms are practically bioterrorism labs. Antibiotics to give the microbes a workout, close proximity of animals so they have lots of environment to evolve in, and rendering so that they stay in the system.
 
 
grant
13:24 / 23.03.04
Early warning from Nature: "Bushmeat seeds new virus".

Apparently, hunters in Central Africa are carrying something new and exciting, and epidemiologists are warning of a new pandemic possibly following HIV out of the jungle.

The virus they've tracked doesn't actually cause an illness, but it does prove that bushmeat can spread bugs wide and fast:

They examined the blood of nearly 1,100 people from nine separate villages for signs of infection with the virus, and report their findings in The Lancet.

Ten people carried antibodies to simian foamy virus in their blood, suggesting they had been exposed to it. And at least three picked up the virus from separate animals - a gorilla, a mandrill and a type of monkey called a De Brazza's guenon - based on comparison of viral DNA sequences in their blood with those from the animals.

"Now we're forced to think these viruses are infecting humans on a much more frequent basis," says study leader Nathan Wolfe of Johns Hopkins University in Baltimore, Maryland.

 
 
sdv (non-human)
16:29 / 24.03.04
Are you not suggesting that a Virus or Bacteria is at the top of the food chain?
 
 
sdv (non-human)
16:43 / 24.03.04
It's probably worth stating that as a side effect of global warming - there will be new structures and patterns that could easily cut back some sections of the human population. As the population heads towards 9 billion its inevitable. A continuation and variation of the AIDS crisis. A body is after all merely a viral and bacterial community, living within a porous great ephemeral skin, within a bacteria infested biosphere. I suppose that we can perhaps think that epidemiology is a model for undertsanding the world - but I have my doubts for I think it just encourages the spectacles tendency towards moral panics...
 
 
grant
18:15 / 24.03.04
Well, I'm not sure the idea of the "food chain" is useful for discussing viruses or bacteria, just because I don't think of them as predators.

The relationship between germs and new population patterns & ecological changes is pretty interesting, though, since it's not as obvious as trees being knocked down and alligators winding up in golf courses.
 
 
Mirror
22:07 / 05.04.04
Vampire bat attacks are on the rise in Brazil with 13 deaths, 6 of which have been confirmed as related to cases of rabies. They suspect changes in bats' migration patterns due to deforestation.
 
 
grant
15:14 / 26.05.06
Study confirms origins of HIV

The fun part:

Scientists employed trackers to plunge through dense jungle and collect the fresh feces of wild apes — more than 1,300 samples in all.

The upshot:

Hahn's team tested chimp feces for SIV antibodies, finding them in a subspecies called Pan troglodytes troglodytes in southern Cameroon.

Chimps tend to form geographically distinct communities. By genetically analyzing the feces, researchers could trace individual infected chimps. The team found some chimp communities with infection rates as high as 35 percent, while others had no infection at all.

Every single infected chimp had a common base genetic pattern that indicated a common ancestor, Hahn said.



and

The first human known to be infected with HIV was a man from Kinshasa in the nearby country of Congo who had his blood stored in 1959 as part of a medical study, decades before scientists knew the AIDS virus existed.

Presumably, someone in rural Cameroon was bitten by a chimp or was cut while butchering one and became infected with the ape virus. That person passed it to someone else.

The Sanaga River long has been a commercial waterway, for transporting hardwood, ivory and other items to more urban areas. Eventually, someone infected made it to Kinshasa.
 
 
ngsq12
23:37 / 29.05.06
I got a handy word for this topic: Zoonoses

Zoonoses are defined by the World Health Organisation as "Diseases and infections which are naturally transmitted between vertebrate animals and man". A zoonotic agent may be a bacterium, virus, fungus, parasite, or other communicable agent. Zoonoses cover a broad range of diseases with different clinical and epidemiological features and control measures.

A good old example is the plague which resides in rats as well as humans.

So this is not a new thing after all. I have heard that the introns in our genome may well code for old parasites that "realised" [!!anthropomorhism warning!!] that if you cant beat 'em join 'em.

You are attached to what you attack. A person infected with giardia no longer needs vitamin b12 in their diet as the parasite makes it for them. So the dividing line between parasite and symbiote is quite a grey area.

Everybody and their mum is always talking about extiction rates but nobody knows the speciation rate. There will be always new bugs coming over the horizon. We will always have to run like the "red queen".
 
 
grant
14:53 / 30.05.06
A person infected with giardia no longer needs vitamin b12 in their diet as the parasite makes it for them.

That's amazing -- I'd never heard that (my daughter tests positive for giarda, even after a course of treatment, but is asymptomatic).

Can you explain more about "introns"?
 
 
Evil Scientist
15:22 / 30.05.06
Here's the wiki for introns. It's a bit technical though.

Nqsq12 is right about there being remnants of viral DNA embedded in our genetic makeup. I'm just searching for something to link to about the subject (my google-fu is weak).

Normally the integrated viral DNA is inactive and serves no purpose for the host organism. I faintly recall there being a feature in New Scientist years ago about some that become active during a human's foetal stage that then go dormant again. But I can't find anything about it online so it may have been a wonderful viral dream.
 
 
grant
16:42 / 30.05.06
They don't want you to know!
 
  
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